Secundum connexionem modum amino acidi et sacchari, saccharo peptidis in quattuor genera dividi potest: O glycosylatio, C a N glycosylatio, saccharificatio ros et nexus GPI (glycophosphatidlyinositol).
1. N-glycosylatio glycopeptides componitur ex N acetamide glucose in fine catenae glycanae (Glc-Nac) redigente cum N atomo in medio globi lateralis catenae alicuius Asn in catena peptide et Asn. cathenam glycanam vincendi capacem in AsN-X-Ser /Thr (X!=P) collocari oportet in argumento a residuo formato.Saccharum N-acetylglucosaminum est.
N-glycosylation structural mutatio glycopeptide
2. Structura glycosylation simplicior est quam N-glycosylatio.Haec glycopeptida fere glycano brevior est, sed plura genera habet quam glycosylation N-.Ser et Thr vulgo glycosylated in catena peptide potest.Sunt praeterea glycopeptides cum tyrosino, hydroxylo, et glycosylatione hydroxyprolineo ornata.Coniunctio positio est atomi hydroxyli oxygenii in residui parte catena.galactosi vel N-acetylgalactosamine (Gal&GalNAc) vel glucosi/glucosamine (Glc/GlcNAc), mannosum/mannosamine (Man/ManNAc) etc.
O-glycosylation modificat structuram
3. glycosylation glycosylation (N-acetylcysteine (NAC)) (glcnAcN-acetylglucosamine/acetylglucosamine)
Glycosylatio unica N-acetylglucosaminum (GlcNAc) connectit proteins O-GlcNAc cum oxygenio hydroxyli atomi serinae vel threoninae reliquiae interdum.O-GlcNA glycosylatio est O-GlcNAc monosaccharidum sine extensione glycanae ornatum;Sicut phosphorylatio peptidis, O-GlcNAc glycosylatio glycopeptidis est etiam processus dapibus dynamicus ornatus.Abnormes O-GlcNAc ornatum varias morbos efficere possunt ut diabetes, morbos cardiovasculares, tumores, morbum Alzheimer et cetera.
Glycosylation puncta glycopeptidi
Fundamenta structurae polypeptidis et catenarum saccharo cum catenis dapibus per vincula covalent iunguntur, et sites vinculorum saccharo vinculorum glycosylationes vocantur sites.Cum nulla sit templates biosynthesim glycopeptidis sequi catenis saccharo, diversae catenulae saccharo eidem glycosylationi site coniunctae erunt, ducens ad inhomogeneitatem microscopicam sic dictam.
Glycosylation of glycopeptides
1. glycopeptidis glycosylationis effectus in justo-efficacia proteins therapeuticae
In servo therapeutico therapeutico, glycosylatio etiam afficit vitam dimidiam ac nisi pharmaca medicamentorum vivo.
2. glycopeptide solutum et glycosylation proteins
Studia demonstraverunt vincula saccharo in superficie proteins ut solutionem hypotheticam emendare possint
3. GLYCOPEPTIDES glycosylatio et interdum immunogenicitas
Ex una parte, saccharo catenis in superficie proteins certis responsa immunia inducere possunt.E contra, saccharum catenae quasdam superficies in superficie interdum operire possunt et eius immunogenitatem minuere
4. GLYCOPEPTIDES glycosylatio quae dapibus stabilitatem auget
Glycosylatio stabilitatem servo augere potest variis conditionibus denaturationi (ut denaturantibus, caloribus, etc.) et aggregationem servo vitare.Eodem tempore, vincula saccharum in superficie servo- rum aliquas dejectiones proteolyticas velare possunt puncta moleculorum interdum, ita resistentia servo ad proteinases augendas.
5. GLYCOPEPTIDES glycosylatio quae afficit actionem biologicam dapibus moleculis
Dapibus glycosylation mutans etiam dapibus moleculis efficere potest ut novas actiones biologicas formare possit
Post tempus: Aug-03-2023